Active member of the French Résistance network Réseau AGIR. Arrested by Gestapo.

Desnos was an active member of the Surrealist group and developed a particular talent for automatic writing. He, together with writers such as Louis Aragon and Paul Éluard, would form the literary vanguard of surrealism.

He attended commercial college, and then worked as a clerk before becoming a literary columnist for the newspaper Paris-Soir.   He first published poems in the Dadaist magazine Littérature in 1919, and in 1922 he published his first book, Prose Selavy, a collection of surrealistic aphorisms. While on leave in Morocco from his mandatory two years in the French Army, Desnos befriended poet Andre Breton. Together with writers Louis Aragon and Paul Eluard, Breton and Desnos would form the vanguard of literary surrealism.   They practiced a technique known as "automatic writing," and many hailed Desnos as the most accomplished practitioner. Breton, in the Manifesto of a trance and then recording the associations and leaps of the subconscious mind. 

Desnos` poems from this time are playful (often using puns and homonyms), sensual, and serious. The 1920s were an extremely creative period for Desnos; between 1920 and 1930, he published more than eight books of poetry, including Language cuit (1923), Deuil pour deuil (1924), Journal d`une apparition (1927), and The Night of Loveless Nights (1930). 

In the 1930s, Desnos diverged slightly from his Surrealist peers. Breton, in his Second Manifesto of Surrealism, 1930, would criticize Desnos for straying from the movement and for his journalistic work. In part, Desnos had simply grown tired of his own excesses—both in his creative and personal life. It was at this time that he married Youki Foujita and took on more commercial writing assignments for French radio and television. 

His poems became more direct and musical, though still maintaining some of their earlier adventurous style. Desnos continued to write throughout the decade; in 1936 he wrote a poem per day for the entire year. His published works from this time include Corps et biens (1930), and Le sans cou (1934). 

In 1939 at the onset of World War II, Desnos again served in the French Army. During the German occupation, he returned to Paris and under pseudonyms such as Lucien Gallois and Pierre Andier, Desnos published a series of essays that subtly mocked the Nazis. These articles combined with his work for the French Resistance led to his arrest. Desnos was sent to first to Auschwitz, and then transferred to a concentration camp in Czechoslovakia. Although the Allies liberated this camp in 1945, Desnos had contracted typhoid. He died on June 8, 1945. 

His Selected Poems were first translated and published in English in 1972, (by William Kulik with Carole Frankel), and again in 1991 (translated by Carolyn Forché and William Kulik).