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Cesar Milstein [1927-2002] Argentinian
Rank: 106
Scientist, Biochemist


César Milstein, CH, FRS was an Argentinian biochemist in the field of antibody research. Milstein shared the Nobel Prize in Physiology or Medicine in 1984 with Niels Kaj Jerne and Georges J. F. Köhler.

Medical



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My father was a Jewish immigrant who settled in Argentina and was left to his own devices at the age of 15. My mother was a teacher, herself the daughter of a poor immigrant family.
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I wasn't a particularly brilliant student, but on the other hand, I was very active in Student Union affairs and in student politics.
102
My thesis was on kinetics studies with the enzyme aldehyde dehydrogenase. When that was finished, I was granted a British Council Fellowship to work under the supervision of Malcolm Dixon.
103
As we returned to Argentina, I started seriously to work towards a doctoral degree under the direction of Professor Stoppani, the Professor of Biochemistry at the Medical School. Medical
104
When an animal is infected, either naturally or by experimental injection, with a bacterium, virus, or other foreign body, the animal recognises this as an invader and acts in such a way as to remove or destroy it.
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What attracted me to immunology was that the whole thing seemed to revolve around a very simple experiment: take two different antibody molecules and compare their primary sequences.
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Back in 1962, when I had by accident become the supervisor of Roberto Celis in Argentina, it occurred to me that antibody diversity might arise from the joining by disulphide bridges of a variety of small polypeptides in combinatorial patterns.
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The study of the amino acid sequence around the disulphide bonds of the immunoglobulins was my own short-cut to the understanding of antibody diversity.
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